The GENCODE human gene set

GENCODE : The reference human genome annotation for The

GENCODE: the reference human genome annotation for The ENCODE Project.

The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation. Since the first public release of this annotation data set, few new protein-coding loci have been added, yet the number of alternative splicing transcripts annotated has steadily increased. The GENCODE 7 release contains 20,...

GEncode: Geometry-driven compression for General Meshes

Performances of actual mesh compression algorithms vary significantly depending on the type of model it encodes. These methods rely on prior assumptions on the mesh to be efficient, such as regular connectivity, simple topology and similarity between its elements. However, these priors are implicit in usual schemes, harming their suitability for specific models. In particular, connectivity–driv...

Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow

Complete annotation of the human genome is indispensable for medical research. The GENCODE consortium strives to provide this, augmenting computational and experimental evidence with manual annotation. The rapidly developing field of proteogenomics provides evidence for the translation of genes into proteins and can be used to discover and refine gene models. However, for both the proteomics an...

Bayesian Gene Set Analysis

Gene expression microarray technologies provide the simultaneous measurements of a large number of genes. Typical analyses of such data focus on the individual genes, but recent work has demonstrated that evaluating changes in expression across predefined sets of genes often increases statistical power and produces more robust results. We introduce a new methodology for identifying gene sets th...